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Lead: Diana Perira (QMUL) Mapping dissociated single-cell data back to spatial coordinates Latent variable models vs anchor-based mapping Handling modality-specific noise and sparsity

Lead: Anthony Baptista (KCL) Sparse matrices, on-disk formats, and parallelisation GPU vs CPU trade-offs in image and transcript integration Algorithmic bottlenecks in neighbourhood graph construction Standardisation across platforms and reproducible benchmarks